The accumulated sebum is subsequently excreted into the hair follicle, where it travels to the skin’s surface, forming a protective film. The enzyme 5-alpha reductase converts testosterone into dihydrotestosterone (DHT), which binds to receptors in the sebaceous gland, stimulating cell growth and lipid synthesis.
How Sebum Production Triggers Acne Breakouts
Hormonal Regulation and Genetic Factors The production of one pore produces an oil called sebum is predominantly regulated by androgens, hormones that surge during puberty, explaining the sudden increase in oiliness during adolescence. External Influences and Sebum Quality Lifestyle and environmental factors significantly impact the quality and quantity of sebum.
Cholesterol and Cholesterol Esters: Vital for maintaining the structural integrity of the skin barrier. This clogged pore becomes a breeding ground for *Cutibacterium acnes* (formerly *Propionibacterium acnes*), bacteria that thrive in the anaerobic environment, triggering inflammation and the formation of acne lesions.
How Sebum Production Triggers Acne
Stress triggers the release of cortisol, which can further stimulate sebaceous activity. This gland is holocrine, meaning that the entire cell disintegrates to release its lipid-rich contents.
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